Disulfiram

(dye sul' fi ram)

Brand Name(s): Antabuse^®; also available generically

IMPORTANT WARNING:

Never give disulfiram to a patient in a state of alcohol intoxication or without the patient's full knowledge. The patient should not take disulfiram for at least 12 hours after drinking. A reaction may occur for up to 2 weeks after disulfiram has been stopped.

WHY is this medicine prescribed?

Disulfiram is used to treat chronic alcoholism. It causes unpleasant effects when even small amounts of alcohol are consumed. These effects include flushing of the face, headache, nausea, vomiting, chest pain, weakness, blurred vision, mental confusion, sweating, choking, breathing difficulty, and anxiety. These effects begin about 10 minutes after alcohol enters the body and last for 1 hour or more. Disulfiram is not a cure for alcoholism, but discourages drinking.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

HOW should this medicine be used?

Disulfiram comes in tablets to take by mouth. It should be taken once a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take disulfiram exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

If you cannot swallow the tablets, crush them and mix the medication with water, coffee, tea, milk, soft drink, or fruit juice.

What SPECIAL PRECAUTIONS should I follow?

Before taking disulfiram,

• tell your doctor and pharmacist if you are allergic to disulfiram or any other drugs.

• tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially amitriptyline (Elavil), anticoagulants ('blood thinners') such as warfarin (Coumadin), isoniazid, metronidazole (Flagyl), phenytoin (Dilantin), any nonprescription drugs that might contain alcohol, and vitamins.

• tell your doctor if you have or have ever had diabetes, thyroid disease, epilepsy, brain damage, or kidney or liver disease.

• tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking disulfiram, call your doctor.

• you should know that this drug may make you drowsy. Do not drive a car or operate machinery until you know how this drug affects you.

What SPECIAL DIETARY instructions should I follow?

Do not drink any alcoholic beverages (including wine, beer, and medications that contain alcohol such as cough syrup) while taking disulfiram, during the 12-hour period before you take your first dose, and for several weeks after stopping the drug.

Avoid sauces, vinegars, and all foods and beverages containing alcohol.

What should I do IF I FORGET to take a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What SIDE EFFECTS can this medicine cause?

Disulfiram may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• skin rash
• acne
• mild headache
• drowsiness
• tiredness
• impotence
• metallic taste or garlic-like taste in the mouth

If you experience any of the following symptoms, call your doctor immediately:

• excessive tiredness
• weakness
• lack of energy
• loss of appetitie
• upset stomach
• vomiting
• yellowness of the skin or eyes
• dark urine

What should I know about STORAGE and DISPOSAL of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

What should I do in case of OVERDOSE?

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

What OTHER INFORMATION should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to disulfiram.

Always carry an identification card stating that you are taking disulfiram and indicating the doctor or institution to be contacted in an emergency. If you need an identification card, ask your pharmacist or doctor how to get one.

Do not come in contact with or breathe the fumes of paint, paint thinner, varnish, shellac, and other products containing alcohol. Exercise caution when applying alcohol-containing products (e.g., aftershave lotions, colognes, and rubbing alcohol) to your skin. These products, in combination with disulfiram, may cause headache, nausea, local redness, or itching. Before using an alcohol-containing product, test it by applying some to a small area of your skin for 1-2 hours. If no redness, itching, or unwanted effects occur, you can use the product safely.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.

The American Society of Health-System Pharmacists, Inc. represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. The information is not a substitute for medical care.

AHFS^® Patient Medication Information™. © Copyright, 2024. The American Society of Health-System Pharmacists^®, 4500 East-West Highway, Suite 900, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.

Selected Revisions: August 15, 2017.